coagulation factor xiii-a a614t gene variation is suggestive of founder effect in iranian patients with sever congenital factor xiii deficiency

background: factor xiii (fxiii) is a heterotetramer composing two subunits including fxiii-a and fxiii-b. several common gene variations were observed in fxiii-a gene with obvious ethnic difference. this study assessed pattern of tyr204phe as a common fxiii-a gene variation among iranian population. materials and methods: this study was conducted on eighty iranian unrelated individuals. genotype analysis for factor xiii-a tyr204phe gene variation was performed for all individuals. results: molecular analysis of these iranian populations revealed that all studied patients were homozygous for tgg cgg mutation at codon 187, in exon 4 of fxiii-a1 gene. conclusion: tyr204phe gene variation is one of the most common mutations of fxiii-a subunit that shows a different pattern in iranian population.